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KMID : 0379520050210020175
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한국독성학회지
2005 Volume.21 No. 2 p.175 ~ p.178
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Uterotrophic and Hershberger Assay for Butyl rho-Hydroxybenzoic Acid
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Ahn Ji-Yun
Kim Sung-Ran
Ha Tae-Youl
Kim Sung-Soo
Han Chan-Kyu
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Abstract
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Butyl rho-hydroxybenzoic acid (butyl paraben, BP) is a homologous series of parabens and is widely used as a preservative in cosmetic and pharmaceutical products. The purpose of this study was to investigate the estrogenic/antiandrogenic activities of BP in animals. For that, we performed an uterotrophic assay and a Hershberger assay in rats. In uterotrophic assay, BP was administered subcutaneously to immature female SD rats (18 days old) for 3 consecutive days. The wet and dry uterus weights were significantly increased in the groups treated with BP in dosedependent manner. In case of Hershberger assay, BP significantly reduced the weight of seminal vesicle of castrated rats. And other accessory organ/glands - prostate, Cowper’’s glands, bulbocavernosus muscle and glans penis were also slightly decreased. The results of this study suggested that BP showed estrogenic and anti-androgenic activities in vivo.
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KEYWORD
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Uterotrophic assay, Hershberger assay
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